Medizinische Universität Graz - Research portal
Selected Publication:
Varga, EM; Eber, E; Zach, MS.
Cold air challenge for measuring airway reactivity in children: lack of a late asthmatic reaction.
Lung. 1990; 168(5):267-272
Doi: 10.1007/BF02719703
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- Leading authors Med Uni Graz
- Varga Eva-Maria
- Co-authors Med Uni Graz
- Eber Ernst
- Zach Maximilian
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- Abstract:
- Cold air challenge (CACh) for measuring airway reactivity uses respiratory heat or water loss as a bronchoconstrictor stimulus; this stimulus is also important for the development of exercise-induced asthma, for which late asthmatic reactions (LARs) have been described. At 1200 hr on day 1, 22 children with asthma started to record their peak expiratory flow rate (PEFR) in 3 hr intervals until 0900 hr on day 2. At 1000 hr, they underwent a standardized 4 min CACh. Children then inhaled salbutamol and continued to record PEFR until 0900 hr on day 3. As a bronchodilator effect, PEFR measurements were significantly higher 2, 5, and 8 hr after CACh, but subsequently did not differ significantly from pre-CACh values. At 5 hr after CACh, individual values ranged from 95 to 137% of the corresponding pre-CACh measurements, at 8 hr from 94 to 150%, and at 11 hr from 80 to 121%. This random sample of children with asthma demonstrated no LAR after CACh.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Airway Resistance - physiology
- Asthma - physiopathology
- Asthma, Exercise-Induced - etiology
- Child - etiology
- Cold - adverse effects
- Female - adverse effects
- Humans - adverse effects
- Hypersensitivity, Delayed - adverse effects
- Immunoglobulin E - analysis
- Male - analysis
- Peak Expiratory Flow Rate - analysis
- Respiratory Mechanics - analysis