Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Smolle-Juettner, FM; Geyer, E; Kapp, KS; Ratzenhofer, B; Stuecklschweiger, G; Kaufmann, NB; Smolle, J; Pongratz, GM; Hackl, A; Friehs, G.
Evaluating intraoperative radiation therapy (IORT) and external beam radiation therapy (EBRT) in non-small cell lung cancer (NSCLC). Five years experience.
Eur J Cardiothorac Surg. 1994; 8(10):511-516
Doi: 10.1016/1010-7940(94)90067-1
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- Führende Autor*innen der Med Uni Graz
- Smolle-Juettner Freyja-Maria
- Co-Autor*innen der Med Uni Graz
- Kapp Karin S.
- Ratzenhofer-Komenda Beatrice
- Smolle Josef
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- Abstract:
- A pilot study on intraoperative radiation therapy (IORT) combined with external beam radiation therapy (EBRT) in nonresectable non-small cell lung cancer (NSCLC) was performed in 31 patients (mean age: 66.2 years, range: 51-80; 10 anatomically and functionally, 21 functionally, nonresectable; 20 squamous-cell, 11 adenocarcinoma). The tumor was exposed by lateral thoracotomy and a staging lymph node dissection was performed (final staging 7 T1, 16 T2, 8 T3; 11 nodal positive). Ten to 20 Gy IORT (energy: 7-20 MeV electrons) were delivered to the tumor. Unilateral continuous positive airway pressure ventilation of the diseased lung was used to reduce the amount of healthy lung tissue in the IORT port and to minimize the ventilatory movement. Secondary collimation and direct shielding of radio-sensitive structures within the IORT port by aluminium sheets were used to further reduce collateral damage. Four weeks after IORT, 46 Gy EBRT (2 Gy/day 5 times a week; 8-23 MeV photons) were administered to the mediastinum and to the tumor-bearing area on an outpatient basis. In nodal positive cases the mediastinal dose was increased to 56 Gy. Twenty-three patients were evaluable. In 13 complete, in 8 partial (50-97% regression) and in 2 minor response has been achieved. Five patients experienced a recurrence (local only: 2; local and distant: 1; distant only: 2). Twelve patients died of underlying cardio-respiratory disorders within 6 to 25 months after IORT; 7 died of cancer. The overall 5-year survival rate including the incidental deaths is 14.7%. The recurrence-free survival rate is 53.2%.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma - mortality
- Adenocarcinoma - radiotherapy
- Adenocarcinoma - surgery
- Aged -
- Aged, 80 and over -
- Carcinoma, Non-Small-Cell Lung - mortality
- Carcinoma, Non-Small-Cell Lung - radiotherapy
- Carcinoma, Non-Small-Cell Lung - surgery
- Carcinoma, Squamous Cell - mortality
- Carcinoma, Squamous Cell - radiotherapy
- Carcinoma, Squamous Cell - surgery
- Disease-Free Survival -
- Female -
- Humans -
- Intraoperative Period -
- Lung Neoplasms - mortality
- Lung Neoplasms - radiotherapy
- Lung Neoplasms - surgery
- Male -
- Middle Aged -
- Pilot Projects -
- Radiation Protection - methods
- Radiotherapy Dosage -
- Survival Rate -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- LUNG NEOPLASMS
- SURGERY
- RADIO-THERAPY