Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Dieber-Rotheneder, M; Puhl, H; Waeg, G; Striegl, G; Esterbauer, H.
Effect of oral supplementation with D-alpha-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation.
J Lipid Res. 1991; 32(8): 1325-1332.
Doi: 10.1016/S0022-2275(20)41962-5
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- Führende Autor*innen der Med Uni Graz
- Dieber-Rotheneder Martina
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- Abstract:
- Twelve clinically healthy subjects participated in a vitamin E supplementation study. Eight were given daily dosages of 150, 225, 800, or 1200 IU RRR-alpha-tocopherol for 21 days (two persons per dose) and four received placebo. Prior, during, and after the supplementation period, alpha-tocopherol, gamma-tocopherol, and carotenoids were determined in plasma and low density lipoprotein (LDL). The maximum levels of alpha-tocopherol were 1.7- to 2.5-times the baseline values in plasma and 1.7- to 3.1-times in LDL. A high correlation existed between alpha-tocopherol in plasma and LDL. gamma-Tocopherol significantly decreased in plasma and LDL during vitamin E supplementation. No significant influence on the lipoprotein and lipid status and carotenoid levels of the participants occurred throughout the supplementation. The resistance of LDL against copper-mediated oxidation was also measured. The oxidation resistance of LDL was significantly higher during vitamin E supplementation. However, the efficacy of vitamin E in protecting LDL varied from person to person. The statistical evaluation of all data gave a correlation of r2 = 0.51 between alpha-tocopherol in LDL and the oxidation resistance as measured by the length of the lag-phase preceding the oxidation of LDL. No association was seen between levels of carotenoids and vitamin E in plasma and LDL. The present study clearly shows that in humans the oxidation resistance of LDL can be increased by vitamin E supplementation.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Oral -
- Adult -
- Carotenoids - blood
- Cholesterol - blood
- Copper - pharmacology
- Dose-Response Relationship, Drug - pharmacology
- Fatty Acids, Unsaturated - blood
- Female - blood
- Humans - blood
- Lipid Peroxidation - blood
- Lipoproteins, LDL - chemistry
- Male - chemistry
- Peroxides - blood
- Single-Blind Method - blood
- Time Factors - blood
- Vitamin E - blood
- Find related publications in this database (Keywords)
- CAROTENOIDS
- LIPID PEROXIDATION
- OXIDIZED LDL