Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Lackner, H; Urban, C; Kaulfersch, W; Slavc, I; Gamillscheg, A; Hauer, C.
Cyclosporin A in severe aplastic anemia in children
Padiatr Padol. 1989; 24(4): 313-320.
(- Case Report)
PubMed
- Führende Autor*innen der Med Uni Graz
- Lackner Herwig
- Co-Autor*innen der Med Uni Graz
- Gamillscheg Andreas
- Hauer Almuthe
- Urban Ernst-Christian
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- Abstract:
- Severe aplastic anemia should be treated with bone marrow transplantation if possible. Various clinical and experimental data support the view that the major pathogenetic defect in SAA is a dysregulated cellular immune response which in turn has a negative effect upon hematopoiesis. Therefore a large percentage of patients react favorably to treatment with immunosuppressive agents as antithymocyte globulin and high-dose methylprednisolone. Data concerning the efficiency of Cyclosporine A treatment are limited until now. We present in this report our own experience with Cyclosporine A treatment in three children with severe aplastic anemia who lack a bone marrow donor. Included is also a review of the present therapeutic possibilities.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Anemia, Aplastic - drug therapy
- Antilymphocyte Serum - administration and dosage
- Cyclosporins - administration and dosage
- Dose-Response Relationship, Drug - administration and dosage
- Drug Therapy, Combination - administration and dosage
- Erythrocyte Count - drug effects
- Female - drug effects
- Hemoglobinometry - drug effects
- Humans - drug effects
- Infant - drug effects
- Male - drug effects
- Methylprednisolone - administration and dosage
- Pregnancy - administration and dosage
- Pregnancy Complications, Hematologic - drug therapy
- Reticulocytes - drug effects