Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Cervar, M; Kainer, F; Desoye, G.
Secretion of endothelin-1 by trophoblast cells and binding of endothelin-1 to trophoblast membranes in healthy and pre-eclampsia pregnancies
Gynakol Geburtshilfliche Rundsch. 1995; 35 Suppl 1(1-2): 42-45.
Doi: 10.1159/000272562
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- Führende Autor*innen der Med Uni Graz
- Cervar-Zivkovic Mila
- Co-Autor*innen der Med Uni Graz
- Desoye Gernot
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- Abstract:
- Objectives: The hypothesis was tested that the synthesis or binding of endothelin-1 (ET-1) by the trophoblast are altered in preeclampsia. Methods: Trophoblast cells (TC) were isolated from 15 normal (C) und 18 pre-eclamptic pregnancies (P). Binding of [I-125]ET-1 to plasma membranes of TC was determined after 48 h in culture. Concentration of ET-1 in culture media were measured after each 24 h over 5 day culture period. Results: Specific binding was 150% (week 37-40) -400% (week 31-36) higher (P<0.01) in P. In contrast, the release of ET-1 was 60% (week 31-36) -71% (week 37-40) lower (P<0.01) in P than in healthy controls. Conclusions: Pre-eclampsia is associated with a lower release and increased binding of ET-1 by trophoblast cells.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Cell Membrane - pathology
- Endothelins - metabolism
- Female - metabolism
- Gestational Age - metabolism
- Humans - metabolism
- Infant, Newborn - metabolism
- Pre-Eclampsia - pathology
- Pregnancy - pathology
- Radioligand Assay - pathology
- Receptor, Endothelin A - pathology
- Receptors, Endothelin - metabolism
- Reference Values - metabolism
- Trophoblasts - pathology