Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gneiss, C; Tripp, P; Ehling, R; Khalil, M; Lutterotti, A; Egg, R; Mayringer, I; Künz, B; Berger, T; Reindl, M; Deisenhammer, F.
Interferon-beta antibodies have a higher affinity in patients with neutralizing antibodies compared to patients with non-neutralizing antibodies.
J Neuroimmunol. 2006; 174(1-2): 174-179.
Doi: 10.1016/j.jneuroim.2006.01.017
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Khalil Michael
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- Abstract:
- In this study, we investigated the affinity, determined by a relative affinity assay, using increasing concentrations of sodium-isothiocyanate to disrupt the antigen antibody binding of neutralizing and non-neutralizing antibodies against interferon-beta (IFNbeta)-1a and -1b in 73 serum samples of MS patients treated with IFNbeta-1a or -1b. Relative affinity values were significantly higher in NAB-positive compared to NAB-negative samples and in samples of IFNbeta-1a-treated patients compared to IFNbeta-1b. A significant positive correlation between relative affinity values and therapy duration indicates affinity maturation as another qualitative factor in IFNbeta neutralization.
- Find related publications in this database (using NLM MeSH Indexing)
- Analysis of Variance -
- Antibodies - physiology
- Binding, Competitive - immunology
- Cross Reactions - immunology
- Enzyme-Linked Immunosorbent Assay - methods
- Humans - methods
- Immunotherapy - methods
- Interferon-beta - immunology
- Multiple Sclerosis - immunology
- Neutralization Tests - methods
- Time Factors - methods
- Treatment Outcome - methods
- Find related publications in this database (Keywords)
- affinity
- interferon-beta
- antibodies
- multiple sclerosis