Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Khalil, M; Reindl, M; Lutterotti, A; Kuenz, B; Ehling, R; Gneiss, C; Lackner, P; Deisenhammer, F; Berger, T.
Epitope specificity of serum antibodies directed against the extracellular domain of myelin oligodendrocyte glycoprotein: Influence of relapses and immunomodulatory treatments.
J Neuroimmunol. 2006; 174(1-2):147-156
Doi: 10.1016/j.jneuroim.2006.01.012
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Khalil Michael
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- Abstract:
- Only few reports are available on the epitope specificity of anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in multiple sclerosis (MS). In the present study we provide a precise characterization of the epitope specificity of serum antibodies directed against the extracellular domain of MOG, including IgG, IgM and IgA immunoglobulin isotypes in 28 relapsing remitting MS patients and report that linear epitopes amino-acid (aa) 37-48 and aa42-53 are immunodominant. Recently experienced relapses intensified the anti-MOG peptide antibody response. Immunomodulatory treatment with interferon-beta or glatiramer-acetate had no major impact on the anti-MOG peptide immunoreactivity after 1 year of therapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Amino Acid Sequence -
- Antibodies - blood
- Antibody Specificity - physiology
- Case-Control Studies - physiology
- Epitopes - blood
- Female - blood
- Humans - blood
- Immunoassay - methods
- Immunologic Factors - therapeutic use
- Male - therapeutic use
- Middle Aged - therapeutic use
- Multiple Sclerosis - prevention and control
- Myelin-Associated Glycoprotein - immunology
- ROC Curve - immunology
- Recurrence - prevention and control
- Sensitivity and Specificity - prevention and control
- Time Factors - prevention and control
- Find related publications in this database (Keywords)
- autoantibody
- myelin oligodendrocyte glycoprotein
- epitopes
- interferon-beta
- glatiramer-acetate
- relapse