Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ehling, R; Lutterotti, A; Wanschitz, J; Khalil, M; Gneiss, C; Deisenhammer, F; Reindl, M; Berger, T.
Increased frequencies of serum antibodies to neurofilament light in patients with primary chronic progressive multiple sclerosis.
Mult Scler. 2004; 10(6):601-606
Doi: 10.1191/1352458504ms1100oa
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Khalil Michael
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- Abstract:
- We investigated whether serum and cerebrospinal fluid (CSF) antibodies to the light subunit of the NF protein (NF-L), a main component of the axonal cytoskeleton, may serve as biological markers for axonal pathology and/or disease progression in multiple sclerosis (MS). IgG to NF-L was measured in sera and CSF of MS patients, patients with inflammatory demyelinating diseases of the PNS, with acute inflammatory neurological diseases (including bacterial and viral meningitis), with neurodegenerative diseases, with acute noninflammatory neurological diseases (including stroke, headache and backache) and healthy controls by enzyme-linked immunosorbent assay. We found that serum anti-NF-L IgG antibodies were significantly elevated in MS patients with primary progressive disease course and we provide evidence for an intrathecal production of these antibodies. Our findings support the use of serum antibodies to NF-L as a marker for axonal destruction.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Animals -
- Antibody Specificity -
- Autoantibodies - blood
- Axons - pathology
- Biological Markers - pathology
- Enzyme-Linked Immunosorbent Assay - pathology
- Female - pathology
- Humans - pathology
- Middle Aged - pathology
- Multiple Sclerosis, Chronic Progressive - immunology
- Neurofilament Proteins - immunology
- Recombinant Proteins - immunology
- Swine - immunology
- Find related publications in this database (Keywords)
- autoantibodies
- axonal pathology
- markers of disease activity
- multiple sclerosis
- neurofilament protein