Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kuenz, B; Lutterotti, A; Khalil, M; Ehling, R; Gneiss, C; Deisenhammer, F; Reindl, M; Berger, T.
Plasma levels of soluble adhesion molecules sPECAM-1, sP-selectin and sE-selectin are associated with relapsing-remitting disease course of multiple sclerosis.
J Neuroimmunol. 2005; 167(1-2):143-149
Doi: 10.1016/j.jneuroim.2005.06.019
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Khalil Michael
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- Abstract:
- Adhesion molecule mediated leukocyte migration into the central nervous system is considered to be a critical step in the pathogenesis of multiple sclerosis (MS). We measured plasma levels of the soluble adhesion molecules sPECAM-1, sP-selectin and sE-selectin in 166 MS patients and in 36 healthy blood donors with ELISA. sPECAM-1, sP-selectin and sE-selectin plasma concentrations showed a significant increase in the relapsing-remitting disease course of MS and were elevated during relapse. These findings indicate that sPECAM-1, sP-selectin and sE-selectin might be implemented as paraclinical markers of disease activity in MS with restriction to the clinical course of the disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Cell Adhesion Molecules - blood
- Disease Progression - blood
- E-Selectin - blood
- Enzyme-Linked Immunosorbent Assay - methods
- Female - methods
- Humans - methods
- Male - methods
- Middle Aged - methods
- Multiple Sclerosis - blood
- P-Selectin - blood
- Find related publications in this database (Keywords)
- multiple sclerosis
- soluble platelet endothelial cell adhesion molecule-1 (sPECAM-1)
- soluble e-selectin (sE-selectin)
- soluble p-selectin (sP-selectin)
- plasma