Medizinische Universität Graz - Research portal
Selected Publication:
Mirzaei, S; Zajicek, SM; Knoll, P; Lipp, C; Lipp, RW; Salzer, H; Umek, H; Kohn, H.
Scintimammography enhances negative predictive value of non-invasive pre-operative assessment of breast lesions.
Eur J Surg Oncol. 2000; 26(8):738-741
Doi: 10.1053/ejso.2000.0995
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PubMed
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- Co-authors Med Uni Graz
- Lipp Rainer
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- Abstract:
- AIMS: The aim of this study was to develop a criterion with a high negative predictive value for the evaluation of breast lesions. We aimed to determine the value of combining three non-invasive tests, mammography (MM), ultrasonography (USS) and 99mTc-methoxyisobutylisonitrite (99mTc-MIBI) scintimammography (scinti-MM). METHODS: We included 94 consecutive patients with suspected lesions detected by mammography or on physical examination. MM, USS and scinti-MM were performed no more than 4 weeks prior to excisional biopsy in all patients. We then compared the biopsy results with a score calculated for each patient, derived from the results of the three tests, which we termed 'mamma malignancy index' (MMI). RESULTS: Each of the three exams yielded a score ranging from 0 to 2, with 0 representing an almost certainly benign lesion, 1 an indeterminate finding and 2 a likely malignant lesion, and hence giving a total score ranging from 0 to 6. The biopsy results showed that the lesions in 64 patients were benign. Forty-nine (77%) of these patients had received an MMI score of 0 or 1. The negative predictive value for malignancy in patients with a score less than 2 was 100%. CONCLUSIONS: Since the smallest detected lesion was 9 mm in diameter, we conclude that MMI may be a highly useful diagnostic tool in the delineation of breast lesions > or =1 cm which should not be routinely referred for biopsy but may be followed non-invasively. Although fine needle aspiration has limitations, we would recommend it as a less invasive method to evaluate suspected lesions smaller than 1 cm.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Biopsy, Needle -
- Breast - pathology
- Breast Diseases - diagnosis
- Breast Neoplasms - diagnosis
- Diagnosis, Differential - diagnosis
- Female - diagnosis
- Humans - diagnosis
- Mammography - diagnosis
- Middle Aged - diagnosis
- Predictive Value of Tests - diagnosis
- Radionuclide Imaging - methods
- Technetium - diagnostic use
- Ultrasonography, Mammary - diagnostic use
- Find related publications in this database (Keywords)
- breast cancer
- biopsy
- scintimammography