Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Quasthoff, S; Adelsberger, H; Grosskreutz, J; Arzberger, T; Schröder, JM.
Immunohistochemical and electrophysiological evidence for omega-conotoxin-sensitive calcium channels in unmyelinated C-fibres of biopsied human sural nerve.
Brain Res. 1996; 723(1-2):29-36
Doi: 10.1016/0006-8993(96)00186-2
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- Führende Autor*innen der Med Uni Graz
- Quasthoff Stefan
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- Abstract:
- In vitro electrophysiological measurements of Ca2+ potentials in human sural nerve fascicles revealed that Ca2+ conductances might be present on unmyelinated C-fibres. Furthermore, these Ca2+ potentials were partially blocked by omega-conotoxin, a calcium antagonist for the N-type Ca2+ channels. Therefore, immunohistochemical staining with indirect immunofluorescent omega-conotoxin GVIA was used to localize N-type Ca2+ channels in intact and in enzymatically dissociated human sural nerve fascicles. Densities of toxin binding sites were highly heterogeneous throughout the different nerve fascicles investigated and putative N-type Ca2+ channels were localized in about 20% of the unmyelinated C-fibres. Myelinating Schwann cells as well as enzymatically demyelinated axons displayed no specific binding indicating the absence of N-type Ca2+ channels.
- Find related publications in this database (using NLM MeSH Indexing)
- Calcium Channel Blockers - pharmacology
- Calcium Channels - drug effects
- Humans - drug effects
- Immunohistochemistry - drug effects
- Nerve Fibers - physiology
- Peptides - pharmacology
- Sural Nerve - physiology
- omega-Conotoxin GVIA - physiology
- Find related publications in this database (Keywords)
- omega-conotoxin GVIA
- voltage-sensitive calcium channel
- C-fiber
- human sural nerve