Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Wächtler, J; Mayer, C; Quasthoff, S; Adelsberger, H; Grafe, P.
P2 purinoceptor-mediated intracellular Ca2+ transients in human sural nerve.
Neuroreport. 1996; 7(7):1289-1292
Doi: 10.1097/00001756-199605170-00014
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- Co-Autor*innen der Med Uni Graz
- Quasthoff Stefan
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- Abstract:
- Segments of biopsied human sural nerve were stained with the Ca(2+)-sensitive fluorescent dyes Calcium Green-1 and Fura Red. The emission ratio was used to follow changes in the intracellular free Ca2+ concentration ([Ca2+]i). Application of ATP and analogues in concentrations between 0.3 and 300 microM via the bathing solution resulted in a transient rise in [Ca2+]i. The rank order of agonist potency, 2-methylthioATP > ATP > UTP, and the failure of adenosine, alpha,beta-MeATP and beta,gamma-MeATP to evoke rises in [Ca2+]i indicate the presence of P2Y/U subtypes of purinoceptors in this preparation. ATP-induced Ca2+ transients in biopsied human nerve preparations might serve as a diagnostic tool in neuropathies.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenosine Triphosphate - pharmacology
- Adult - pharmacology
- Aged - pharmacology
- Calcium - metabolism
- Humans - metabolism
- Middle Aged - metabolism
- Neuroglia - drug effects
- Receptors, Purinergic P2 - drug effects
- Sural Nerve - drug effects
- Time Factors - drug effects
- Find related publications in this database (Keywords)
- human sural nerve
- Schwann cell
- neuropathy
- ATP
- purinoceptors
- intracellular calcium
- Calcium Green-1
- Fura Red