Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Grosskreutz, J; Quasthoff, S; Kühn, M; Grafe, P.
Capsaicin blocks tetrodotoxin-resistant sodium potentials and calcium potentials in unmyelinated C fibres of biopsied human sural nerve in vitro.
Neurosci Lett. 1996; 208(1):49-52
Doi: 10.1016/0304-3940(96)12536-2
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- Co-Autor*innen der Med Uni Graz
- Quasthoff Stefan
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- Abstract:
- Topical application of capsaicin has been tested recently for treatment of painful peripheral neuropathy. In the present study, effects of capsaicin were explored on compound action potentials of isolated fascicles from human sural nerve biopsies. Capsaicin reduced the C fibre component by 30-60%; the remaining C fibres were not sensitive to the drug. A good correlation was found between the sensitivity of C fibres to capsaicin and their resistance to tetrodotoxin (TTX), i.e. C fibre action potentials recorded in the presence of TTX were completely blocked by capsaicin. Calcium action potentials seen after inhibition of axonal potassium conductances were also completely suppressed. The data indicate that application of capsaicin nearby human peripheral nerves might prevent action potential conduction in specific subtypes of C fibres.
- Find related publications in this database (using NLM MeSH Indexing)
- Action Potentials - drug effects
- Calcium - physiology
- Capsaicin - pharmacology
- Humans - pharmacology
- Nerve Fibers - physiology
- Sodium - physiology
- Sural Nerve - cytology
- Tetrodotoxin - antagonists and inhibitors
- Find related publications in this database (Keywords)
- capsaicin
- human sural nerve
- tetrodotoxin resistance
- calcium potentials
- neuropathy