Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Quasthoff, S.
A mechanosensitive K+ channel with fast-gating kinetics on human axons blocked by gadolinium ions.
Neurosci Lett. 1994; 169(1-2):39-42
Doi: 10.1016/0304-3940(94)90351-4
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Quasthoff Stefan
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Current recordings from single mechanosensitive potassium channels were obtained from cell-attached and excised patches of human axons. The channel showed an inwardly rectifying I-V relationship with a slope conductance of 52 pS at negative potentials (symmetrical high potassium solution). The fast-gating kinetics of the channel were best described by one time constant for the open state and two time constants for the closed state. The open probability of this channel increased as negative pressure was applied to the patch pipette. The pressure dependence of the open probability of the mechanosensitive K+ channel followed a sigmoid relationship. Gadolinium (0.5-1 mM) acted as a potent blocker when applied to the intra- and extracellular side of the patch membrane.
- Find related publications in this database (using NLM MeSH Indexing)
- Axons - drug effects
- Cell Membrane - drug effects
- Gadolinium - pharmacology
- Humans - pharmacology
- Ion Channel Gating - drug effects
- Kinetics - drug effects
- Mechanoreceptors - drug effects
- Nerve Fibers, Myelinated - physiology
- Neuromuscular Diseases - metabolism
- Potassium Channels - drug effects
- Sural Nerve - cytology
- Find related publications in this database (Keywords)
- HUMAN AXON
- SURAL NERVE
- MYELINATED FIBER
- PATCH CLAMP
- MECHANOSENSITIVE POTASSIUM CHANNEL
- GADOLINIUM ION