Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Mitrovic, N; Quasthoff, S; Grafe, P.
Sodium channel inactivation kinetics of rat sensory and motor nerve fibres and their modulation by glutathione.
Pflugers Arch. 1993; 425(5-6):453-461
Doi: 10.1007/BF00374872
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Quasthoff Stefan
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- Abstract:
- Na+ channel currents of rat motor and sensory nerve fibres were studied with the patch-clamp technique on enzymatically demyelinated axons. Differences between motor and sensory fibres in multi-channel inactivation kinetics and the gating of late single-channel currents were investigated. In the axon-attached mode, inactivation of multi-channel Na+ currents in sensory axons was best fitted with a single time constant while for motor axons two time constants were needed. Late single-channel currents in sensory axons were characterized by short openings whereas motor axons exhibited additional long single-channel openings. In contrast, in excised, inside-out membrane patches, no differences between motor and sensory fibres were found; in both types of fibre inactivation of multi-channel Na+ currents proceeded with two time constants and late single-channel currents showed short and long openings. After application of the reducing agent glutathione to the cytoplasmic side of excised inside-out patches, inactivation of Na+ currents in both motor and sensory fibres proceeded with a single, fast exponential time constant and late currents appeared with short openings only. These data indicate that the axonal metabolism may contribute to the different inactivation kinetics of Na+ current in motor and sensory nerve fibres.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Axons - drug effects
- Glutathione - pharmacology
- Kinetics - pharmacology
- Male - pharmacology
- Motor Neurons - metabolism
- Nerve Fibers - metabolism
- Neurons, Afferent - metabolism
- Rats - metabolism
- Rats, Wistar - metabolism
- Sodium Channels - drug effects
- Find related publications in this database (Keywords)
- AXON
- PERIPHERAL NERVE
- PATCH CLAMP
- ION CHANNELS
- METABOLISM
- GLUTATHIONE
- IODATE
- MONOCHLOROBIMANE