Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Quasthoff, S; Franke, C; Hatt, H; Richter-Turtur, M.
Two different types of potassium channels in human skeletal muscle activated by potassium channel openers.
Neurosci Lett. 1990; 119(2):191-194
Doi: 10.1016/0304-3940(90)90831-S
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- Führende Autor*innen der Med Uni Graz
- Quasthoff Stefan
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- Abstract:
- The inside-out patch clamp technique was used to record the effects of K+ channel openers (EMD 52692, RP 49356 and Cromakalim) on single channel currents in membrane blebs of human skeletal muscle. Two types of K+ channels were activated by these drugs: an ATP-sensitive K+ channel which was inhibited by 3 mM ATP and 5 microM Glibenclamide and an ATP insensitive K+ channel. The open probability of both types was strongly increased by K+ channel openers. Glibenclamide antagonized the action of the K+ channel openers.
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