Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Quasthoff, S; Spuler, A; Spittelmeister, W; Lehmann-Horn, F; Grafe, P.
K+ channel openers suppress myotonic activity of human skeletal muscle in vitro.
Eur J Pharmacol. 1990; 186(1):125-128
Doi: 10.1016/0014-2999(90)94068-9
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- Führende Autor*innen der Med Uni Graz
- Quasthoff Stefan
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- Abstract:
- Isolated fibre bundles from myotonic human skeletal muscle showed after-contractions and spontaneous mechanical activity. The K+ channel openers cromakalim (10-100 mumols/l) and EMD 52962 (1-10 mumols/l) completely suppressed these abnormalities in mechanical activity. Voltage-clamp experiments revealed that cromakalim (100 mumols/l) increased the membrane K+ conductance of isolated, non-myotonic human skeletal muscle fibres 4-fold; Cl- conductance was not altered. The data show that myotonia is suppressed by an increase in in membrane K+ conductance.
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