Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Martino, R; Parody, R; Fukuda, T; Maertens, J; Theunissen, K; Ho, A; Mufti, GJ; Kroger, N; Zander, AR; Heim, D; Paluszewska, M; Selleslag, D; Steinerova, K; Ljungman, P; Cesaro, S; Nihtinen, A; Cordonnier, C; Vazquez, L; López-Duarte, M; Lopez, J; Cabrera, R; Rovira, M; Neuburger, S; Cornely, O; Hunter, AE; Marr, KA; Dornbusch, HJ; Einsele, H.
Impact of the intensity of the pretransplantation conditioning regimen in patients with prior invasive aspergillosis undergoing allogeneic hematopoietic stem cell transplantation: A retrospective survey of the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation.
BLOOD. 2006; 108(9): 2928-2936.
Doi: 10.1182/blood-2006-03-008706
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- Co-Autor*innen der Med Uni Graz
- Dornbusch Hans Jürgen
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- Abstract:
- In this retrospective study, we analyzed the outcomes of 129 patients who underwent an allogeneic hematopoietic stem cell transplantation (allo-HSCT) and had a history of probable or proven invasive aspergillosis (IA), of whom 57 (44%) received a reduced-intensity conditioning (RIC). Overall, 27 patients with IA progressed after the allo-HSCT (cumulative incidence [CumInc] at 2 years, 22%). The variables that increased the 2-year CumInc of IA progression were (1) longer duration of neutropenia after transplantation; (2) advanced status of the underlying disease; and (3) less than 6 weeks from start of systemic anti-Aspergillus therapy and the allo-HSCT. In addition, (4) conventional myeloablative conditioning increased the risk of progression early after transplantation (before day 30) only, while 3 variables increased the risk beyond day 30 were (5) cytomegalovirus disease; (6) bone marrow or cord blood as source of stem cells; and (7) grades II to IV acute graft-versus-host disease (GVHD). A risk model for progression was generated, defined as low (0-1 risk factors, 6% incidence), intermediate (2-3 risk factors, 27% incidence), or high risk (> or = 3 risk factors, 72% incidence [P < .001]). These findings may help in the interpretation and design of future studies on secondary prophylaxis of IA after an allo-HSCT.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aspergillosis - complications
- Bone Marrow Transplantation - complications
- Child - complications
- Child, Preschool - complications
- Cytomegalovirus Infections - epidemiology
- Europe - epidemiology
- Female - epidemiology
- Hematopoietic Stem Cell Transplantation - methods
- Humans - methods
- Male - methods
- Middle Aged - methods
- Retrospective Studies - methods
- Transplantation Conditioning - methods