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Selected Publication:
Woehlck, HJ; Vicenzi, MN; Bosnjak, ZJ; Atlee, JL.
Anesthetics and automaticity of dominant and latent pacemakers in chronically instrumented dogs. I. Methodology, conscious state, and halothane anesthesia: comparison with and without muscarinic blockade during exposure to epinephrine.
Anesthesiology. 1993; 79(6): 1304-1315.
Doi: 10.1097/00000542-199312000-00022
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- Co-authors Med Uni Graz
- Vicenzi Martin
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- Abstract:
- BACKGROUND: Supraventricular dysrhythmias are common during anesthesia, but have been incompletely investigated. Mechanisms may involve altered automaticity of subsidiary pacemakers and participation of vagal reflexes. The following hypotheses were tested: (1) shifts from the sinoatrial (SA) node to subsidiary pacemakers require intact vagal reflexes and (2) halothane sensitizes the heart to epinephrine-induced atrial pacemaker shifts. METHODS: Epicardial electrodes were implanted in eight dogs on both atrial appendages, the right ventricle, along the sulcus terminalis, and at the His bundle. Weekly testing awake (control), awake with atropine methylnitrate, with 1 and 2 micrograms epinephrine.kg-1.min-1 (3 min-infusions), and under 1.25 and 2 MAC halothane was performed. Electrograms were analyzed for the site of earliest activation (SEA), which was scored 1-6 depending on the distance from the SA node, and expressed as the SEA value. RESULTS: In conscious dogs (control) and at 1.25 MAC halothane, epinephrine increased the SEA values (shifted activation from SA node) and blood pressure, and decreased heart rate; however, with atropine, SEA values were unaffected by epinephrine, although blood pressure and heart rate were elevated. At 2 MAC, atropine did not affect the epinephrine-induced increase in SEA values. Halothane increased SEA values when combined with 1 micrograms epinephrine.kg-1.min-1. CONCLUSIONS: Pacemaker shifts account for atrial dysrhythmias in the conscious state and during 1.25 MAC halothane with epinephrine, and require vagal participation. Halothane sensitizes the heart to epinephrine-induced atrial dysrhythmias. Atropine and halothane facilitate His bundle beats during exposure to epinephrine.
- Find related publications in this database (using NLM MeSH Indexing)
- Anesthesia -
- Animals -
- Arrhythmias, Cardiac - etiology
- Blood Pressure - drug effects
- Cardiac Pacing, Artificial -
- Dogs -
- Epinephrine - pharmacology
- Female -
- Halothane - pharmacology
- Heart Rate - drug effects
- Male -
- Parasympatholytics - pharmacology
- Receptors, Muscarinic - drug effects Receptors, Muscarinic - physiology
- Sinoatrial Node - drug effects Sinoatrial Node - physiology
- Find related publications in this database (Keywords)
- ANIMAL, DOG
- ANESTHETIZED
- DOG, CONSCIOUS
- ANESTHETICS, VOLATILE, HALOTHANE
- HEART ARRHYTHMIAS
- AUTONOMIC REGULATION
- SINOATRIAL NODE
- SUBSIDIARY ATRIAL PACEMAKERS
- PARASYMPATHETIC NERVOUS SYSTEM, ACETYLCHOLINE, SYMPATHETIC NERVOUS SYSTEM, CATECHOLAMINES, EPINEPHRINE