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Laberge, S; Pinsonneault, S; Varga, EM; Till, SJ; Nouri-Aria, K; Jacobson, M; Cruikshank, WW; Center, DM; Hamid, Q; Durham, SR.
Increased expression of IL-16 immunoreactivity in bronchial mucosa after segmental allergen challenge in patients with asthma.
J ALLERG CLIN IMMUNOL 2000 106: 293-301. Doi: 10.1067/mai.2000.108112
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Co-authors Med Uni Graz: Varga Eva-Maria
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Abstract:: BACKGROUND: We have previously shown increased expression of the CD4(+) cell chemoattractant IL-16 in bronchial mucosa of patients with asthma. We investigated the effects of allergen challenge on airway IL-16 expression. METHODS: We investigated the expression of IL-16 immunoreactivity in bronchial biopsy samples obtained from atopic asthmatic subjects (n = 19) and normal subjects (n = 6) 24 hours after segmental allergen challenge. Control biopsy samples were obtained either at baseline or after diluent challenge. IL-16 expression was correlated to numbers of CD4(+) cells, CD25(+) cells, and activated eosinophils. IL-16 bioactivity was assessed in bronchoalveolar fluid obtained from patients with asthma. RESULTS: IL-16 expression was higher in control biopsy specimens obtained from subjects with asthma compared with normal subjects (P<.05). In patients with asthma, numbers of IL-16 immunoreactive cells were significantly higher in biopsy specimens obtained after allergen challenge compared with control biopsy specimens (P<.001). Allergen provocation was associated with release of IL-16 in bronchoalveolar fluid in patients with asthma. In normal subjects, there was no difference in the number of IL-16-immunoreactive cells in biopsy specimens obtained after allergen challenge compared with biopsy specimens obtained after diluent challenge. Allergen challenge was associated with an increase in the numbers of EG2(+) eosinophils in patients with asthma but not in normal subjects. IL-16 expression correlated with the numbers of CD4(+) cells and CD25(+) cells after allergen challenge in asthmatic subjects with a provocative concentration required to decrease the FEV(1) by 20% of its baseline value (PC(20)FEV(1)) < 4 mg/mL. IL-16-immunoreactive cells were identified mainly as T cells and eosinophils in asthmatic subjects after allergen challenge. CONCLUSION: Endobronchial allergen provocation in atopic asthmatic patients resulted in increased airway expression of IL-16 and release of bioactive IL-16 in airways. IL-16 may contribute to the immunoregulation of the inflammatory infiltrate in the airways in response to antigen.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Allergens - pharmacology; Asthma - immunology; Bronchi - immunology; Bronchial Provocation Tests - immunology; Bronchoalveolar Lavage Fluid - chemistry; CD4-Positive T-Lymphocytes - cytology; Chemotactic Factors - metabolism; Eosinophils - chemistry; Female - chemistry; Humans - chemistry; Interleukin-16 - genetics; Lymphocyte Count - genetics; Male - genetics; Phenotype - genetics; Receptors, Interleukin-2 - analysis; Respiratory Mucosa - chemistry
Find related publications in this database (Keywords): asthma; IL-16; segmental challenge; lymphocyte; chemotaxis