Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Cimenti, C; Koestenberger, M; Leschnik, B; Haidl, H; Muntean, W.
The respective and combined anticoagulant effects of recombinant human activated protein C, melagatran and heparins using CAT.
Thromb Res. 2007; 119(3): 361-367.
Doi: 10.1016/j.thromres.2006.03.004
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Cimenti Christina
- Co-Autor*innen der Med Uni Graz
- Haidl Harald
- Koestenberger Martin
- Leschnik Bettina
- Muntean Eugen
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Introduction: Combinations of anticoagulants might be beneficial in some patients with sepsis, but most anticoagulants require specific clotting assays for monitoring. Thrombin generation assay, however, is a global function test of hemostasis. Materials and methods: We performed an in vitro investigation of the respective effects of recombinant human activated protein C (rhAPC) alone and in combination with either melagatran (a new direct thrombin inhibitor), unfractionated heparin (UH) or low molecular weight heparin (LMWH) in varying concentrations on the thrombin generation (TG) using the calibrated automated thrombography. Results: RhAPC, UH, LMWH and melagatran dose- dependently prolonged the tag time and the time to peak, and significantly suppressed the endogenous thrombin potential (ETP). Combined application of rhAPC with either metagatran, UH or LMWH induced an additive prolongation of the Lag time; this effect was more pronounced in a combination of rhAPC with UH or LMWH. Conclusion: In our in vitro study adding either melagatran, UH or LMWH augmented the capacity of rhAPC to suppress thrombin generation in human plasma. These findings suggest that patients with severe sepsis might benefit from a treatment with combinations of anticoagulant agents. (c) 2006 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Anticoagulants - pharmacology
- Azetidines - agonists
- Benzylamines - agonists
- Blood Coagulation - drug effects
- Blood Coagulation Tests - drug effects
- Drug Combinations - drug effects
- Drug Synergism - drug effects
- Female - drug effects
- Heparin, Low-Molecular-Weight - agonists
- Humans - agonists
- Male - agonists
- Protein C - agonists
- Recombinant Proteins - agonists
- Sepsis - drug therapy
- Thrombin Time - drug therapy
- Find related publications in this database (Keywords)
- thrombin generation
- rhAPC
- melagatran
- calibrated automated thrombography