Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gruber, T; Barsig, J; Pfeifhofer, C; Ghaffari-Tabrizi, N; Tinhofer, I; Leitges, M; Baier, G.
PKCdelta is involved in signal attenuation in CD3+ T cells.
Immunol Lett. 2005; 96(2): 291-293.
Doi: 10.1016/j.imlet.2004.08.011
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Ghaffari Tabrizi-Wizsy Nassim
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- Abstract:
- PKCdelta has been implicated in the signalling events after engagement of the antigen specific receptor on B cells and the Fc-epsilon receptor on mast cells. Employing our recently established PKCdelta null mice , we here investigate the physiological function of PKCdelta in CD3+ T cells. As result, administration of anti-CD3 antibodies in vivo induced markedly increased blood plasma IL-2 levels (but not IL-4, IFN-gamma, TNF-alpha and IL-6 levels) in the PKCdelta null mice, when compared to wild-type sibling controls. Additionally, in vitro T cell proliferative responses to allogenic MHC are significantly enhanced in PKCdelta-deficient CD3+ T cells. These findings suggest that PKCdelta serves a so far unrecognized role in TCR-induced negative regulation of IL-2 cytokine production and T cell proliferation.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antibodies - administration and dosage
- Antigens, CD3 - analysis
- Interleukin-4 - blood
- Lymphocyte Activation - physiology
- Mice - physiology
- Mice, Mutant Strains - physiology
- Protein Kinase C - genetics
- Protein Kinase C-delta - genetics
- Receptors, Antigen, T-Cell - physiology
- Signal Transduction - physiology
- T-Lymphocytes - enzymology
- Find related publications in this database (Keywords)
- T-lymphocyte
- PKC delta
- TCR/CD3
- IL-2
- cell cycle regulation