Medizinische Universität Graz - Research portal
Selected Publication:
Kleiter, N; Artner, I; Gmachl, N; Ghaffari-Tabrizi, N; Kratochwil, K.
Mutagenic transgene insertion into a region of high gene density and multiple linkage disruptions on mouse chromosome 11.
Cytogenet Genome Res. 2002; 97(1-2):100-105
Doi: 10.1159/000064062
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- Co-authors Med Uni Graz
- Ghaffari Tabrizi-Wizsy Nassim
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- Abstract:
- We have characterized a 185-kb contig surrounding a transgene on distal mouse chromosome 11, the insertion of which has caused a recessive phenotype with skeletal malformations. By cDNA selection and sequencing we have found six genes (Lasp1, Rpl23, Mllt6, Pip5k2b, Psmb3, Zfp144), one truncated gene (Mel13), and one pseudogene (Rps15-ps) within this region. The murine Mllt6 gene is new, it was identified by its high homology (90% identity) with the human homologue MLLT6. Psmb3 and Pip5k2b had not yet been assigned to mouse chromosomes. A comparison with the corresponding region on human chromosome 17q12 revealed several small-scale rearrangements during evolutionary divergence within this cluster of densely packed genes.
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