Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Wilda, M; Ghaffari-Tabrizi, N; Reisert, I; Utermann, G; Baier, G; Hameister, H.
Protein kinase C isoenzyme: selective expression pattern of protein kinase C-θ during mouse development.
Mech Dev. 2001; 103(1-2):197-200
Doi: 10.1016/S0925-4773(01)00357-4
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- Co-Autor*innen der Med Uni Graz
- Ghaffari Tabrizi-Wizsy Nassim
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- Abstract:
- Protein kinase C (PKC)-θ, a serine/threonine protein kinase and novel PKC subfamily member, has been recently identified as an essential component of the T cell synapse which activates the NF-kB signaling cascade leading to expression of the IL-2 gene during T cell activation. By RNA in situ hybridization to whole-body embryo sections it is shown that the murine PKCθ is specifically expressed in tissues with hematopoietic and lymphopoietic activity. Expression is also evident in skeletal muscle. A further highly specific expression was observed in the peripheral and central nervous system which is described in detail. Expression in the brain persists up to adult stages.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Brain - embryology
- Cerebellum - embryology
- DNA, Complementary - metabolism
- Gene Expression -
- Isoenzymes - biosynthesis
- Mice -
- Mice, Inbred C57BL -
- Protein Kinase C - biosynthesis
- Tissue Distribution -
- Find related publications in this database (Keywords)
- protein kinase C-theta
- RNA in situ hybridization
- hematopoiesis
- lymphopoiesis
- yolk sac
- liver
- thymus
- spleen
- afferent neuronal conduction
- dorsal root ganglia
- trigeminal and facial ganglia
- alar plate
- gracile and cuneate fasciculi
- medial lemniscus
- thalamus
- olfactory system
- mitral cell layer
- of olfactory bulb
- interneuron layer of praepiriform cortex amygdaloid area
- medial habenulae
- cerebellum
- choroid plexus