Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Graefen, M; Augustin, H; Karakiewicz, PI; Hammerer, PG; Haese, A; Palisaar, J; Fernandez, S; Noldus, J; Erbersdobler, A; Cagiannos, I; Scardino, PT; Kattan, MW; Huland, H.
Can nomograms derived in the U.S. applied to German patients? A study about the validation of preoperative nomograms predicting the risk of recurrence after radical prostatectomy
UROLOGE A. 2003; 42(5): 685-692.
Doi: 10.1007/s00120-002-0251-x
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Augustin Herbert
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- In patients suffering from prostate cancer, preoperative nomograms, which predict the risk of recurrence may provide a helpful tool in regard to the counselling and planning of an appropriate therapy. The best known nomograms were published by the Baylor College of Medicine, Houston and the Harvard Medical School, Boston. We investigated these nomograms derived in the U.S. when applied to German patients. Data from 1003 patients who underwent radical prostatectomy at the University-Hospital Hamburg were used for validation. Nomogram predictions of the probability for 2-years (Harvard nomogram) and 5-years (Kattan nomogram) freedom from PSA recurrence were compared with actual follow-up recurrence data using areas under the receiver-operating-characteristic curves (AUC). The recurrence free survival after 2 and 5 years was 78% and 58%, respectively. The AUC of the Harvard nomogram predicting 2-years probability of freedom from PSA recurrence was 0.80 vs. Kattan-Nomogram 5-years prediction of 0.83. Thereby, the Kattan nomogram showed a significant higher predictive accuracy (p=0.0274). For that reason preoperative nomograms derived in the U.S. can be applied to german patients. However, we would recommend the utilization of the Kattan nomogram due to its higher predictive accuracy.
- Find related publications in this database (using NLM MeSH Indexing)
- Biopsy - statistics and numerical data
- Cross-Cultural Comparison - statistics and numerical data
- Disease-Free Survival - statistics and numerical data
- Germany - statistics and numerical data
- Humans - statistics and numerical data
- Male - statistics and numerical data
- Models, Statistical - statistics and numerical data
- Neoplasm Recurrence, Local - mortality
- Neoplasm Staging - statistics and numerical data
- Prostate - pathology
- Prostate-Specific Antigen - blood
- Prostatectomy - statistics and numerical data
- Prostatic Neoplasms - mortality
- ROC Curve - mortality
- Reference Values - mortality
- Reproducibility of Results - mortality
- Risk - mortality
- Tumor Markers, Biological - blood
- United States - blood
- Find related publications in this database (Keywords)
- prostate cancer
- radical prostatectomy
- prognosis
- nomogram
- recurrence