Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Mitterbauer, G; Födinger, M; Scherrer, R; Knöbl, P; Jäger, U; Laczika, K; Schwarzinger, I; Gaiger, A; Geissler, K; Greinix, H.
PCR-monitoring of minimal residual leukaemia after conventional chemotherapy and bone marrow transplantation in BCR-ABL-positive acute lymphoblastic leukaemia.
Br J Haematol. 1995; 89(4):937-941
Doi: 10.1111/j.1365-2141.1995.tb08444.x
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
- Linkesch Werner
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- We report the results of consecutive tests in nine BCR-ABL-positive ALL patients by one-step and two-step (nested primer) reverse transcriptase-polymerase chain reaction (RT-PCR). Six patients could be tested in complete haematological remission (CHR). One patient remained one-step positive; four patients became one-step negative, but remained two-step positive; only one patient became two-step negative. In five patients the haematological relapse was preceded by one-step positivity by 1.5-5 weeks. In two patients who received autologous BMT in CHR, BCR-ABL was still detectable by two-step PCR, whereas allogeneic BMT was able to transiently reduce BCR-ABL below the two-step detection level. Our results show that one-step combined with two-step RT-PCR analysis gives valuable information about the efficacy of treatment and the dynamics of the leukaemic clone.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Antineoplastic Agents - therapeutic use
- Bone Marrow Transplantation -
- Fusion Proteins, bcr-abl - analysis
- Humans -
- Middle Aged -
- Neoplasm, Residual - diagnosis
- Polymerase Chain Reaction -
- Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
- Find related publications in this database (Keywords)
- ACUTE LYMPHOBLASTIC LEUKEMIA
- BCR-ABL
- PCR MONITORING
- MINIMAL RESIDUAL DISEASE
- CHEMOTHERAPY BONE MARROW TRANSPLANTATION