Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Habermann, W; Zanarotti, U; Groell, R; Wolf, G; Stammberger, H; Sutter, B; Pendl, G.
Combination of surgery and gamma knife radiosurgery--a therapeutic option for patients with tumors of nasal cavity or paranasal sinuses infiltrating the skull base.
Acta Otorhinolaryngol Ital. 2002; 22(2):74-79
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- Führende Autor*innen der Med Uni Graz
- Habermann Walter
- Co-Autor*innen der Med Uni Graz
- Groell Reinhard
- Stammberger Heinz
- Sutter Bernhard
- Wolf Gerald
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- Abstract:
- The purpose of this study was to investigate whether patients operated for skull base-infiltrating malignant tumors of the nasal cavity and/or the paranasal sinuses benefit from an additional Gamma knife radiosurgery. Case series: eight consecutive patients, (male: female ratio = 1:1, mean age = 52 years, range 34 to 79 years) presented with 2 cyclindric cell carcinomas, 2 adenocarcinomas, 2 malignant neuroblastomas, 1 squamous cell carcinoma, 1 amelanotic melanoma. Tumor stages (UICC) were: 1 T1, 3 T2, 3 T3, 1 T4, all N0, all M0. All patients were primarily treated surgically and 4 weeks later received additional stereotactic radiosurgery. Follow-up was based on computerized tomography (CT), magnetic resonance imaging (MRI), endoscopy, and biopsy. The course of disease was compared to tumor courses with surgery but without radiosurgery reported in literature. Four times endoscopic endonasal surgery (EES), once EES in combination with fluorescein technique, once EES plus external approach of frontal sinus, once lateral rhinotomy was performed. All 8 cases underwent radiosurgery (Leksell gamma knife) 4 weeks after surgery. Thirty six months after radiosurgery 6 patients were alive (4 patients without evidence of disease, 1 patient with pulmonary metastasis but without local recurrence, 1 patient with regional metastasis but no local recurrence), 1 patient died 11 months after treatment due to disease, 1 patient died due to a second malignancy. No negative or adverse effects due to radiosurgery were observed. The combination of microsurgery with Leksell Gamma knife radiosurgery appears to be an encouraging therapeutic option. To date no adverse effects have been observed in the presented cases.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery
- Female -
- Humans -
- Male -
- Melanoma, Amelanotic - pathology Melanoma, Amelanotic - surgery
- Middle Aged -
- Neoplasm Invasiveness - pathology
- Neoplasm Staging -
- Paranasal Sinus Neoplasms - pathology Paranasal Sinus Neoplasms - surgery
- Radiosurgery - instrumentation
- Skull Base Neoplasms - pathology Skull Base Neoplasms - surgery