Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schröttner, O; Unger, F; Eder, HG; Feichtinger, M; Pendl, G.
Gamma-Knife radiosurgery of mesiotemporal tumour epilepsy observations and long-term results.
Acta Neurochir Suppl. 2002; 84(12): 49-55.
Doi: 10.1007/978-3-7091-6117-3_5
PubMed
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- Co-Autor*innen der Med Uni Graz
- Eder Hans
- Feichtinger Michael
- Unger Frank
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- Abstract:
- PURPOSE: The efficacy of radiosurgery in cases of mesiotemporal tumours associated with long standing epilepsy has not clearly been documented up to now. The authors present a retrospective analysis of 19 cases treated by Gamma-Knife radiosurgery (GKRS) for mesiotemporal tumour epilepsy. METHODS: Between 1992 and 1997 19 patients (12 male and 7 female) with a mean age of 31 years (5-72) and mesiotemporal tumour-induced epilepsy of a mean duration of 8.6 years (0.9-28) were treated by GKRS. All tumours were within the mesiotemporal structures and the pathohistology proven by biopsy or resective procedure revealed 15 (79%) low grade astrocytomas, 3 (16%) gangliogliomas and 1 (5%) cavernoma. Beside tumour control, the main aim of GKRS was alleviation of epilepsy by irradiating the presumed epileptic foci outside the tumour volume. The 50% isodose volumes surrounding the tumours measured a mean of 6.2 ccm (1.1-18 ccm). Doses given at marginal isodoses ranged from 12 to 30 Gy (mean 17.3 Gy). The outcome with respect to epileptic seizures was evaluated by the Engel classification. RESULTS: After a follow-up (FU) of 1.7 to 9.7 years (mean 6.5 years) 11 patients (57.9%) were significantly ameliorated (Engel I and Engel II), 7 patients (36.8%) worthwhile improved (Engel III) and 1 patient (5.3%) unchanged. In 11 patients (58%) radiosurgically induced image changes were seen on MRI. INTERPRETATION: Although microsurgical approach guided by electrocorticography (EcoG) is the state of art for treatment of mesiotemporal tumour epilepsy, GKRS can be used as a non-invasive, safe and effective alternative to resective surgery for selected cases.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Astrocytoma - diagnosis
- Brain Neoplasms - diagnosis
- Child - diagnosis
- Child, Preschool - diagnosis
- Epilepsy, Complex Partial - diagnosis
- Epilepsy, Temporal Lobe - diagnosis
- Female - diagnosis
- Follow-Up Studies - diagnosis
- Ganglioglioma - diagnosis
- Hemangioma, Cavernous, Central Nervous System - diagnosis
- Humans - diagnosis
- Magnetic Resonance Imaging - diagnosis
- Male - diagnosis
- Middle Aged - diagnosis
- Outcome and Process Assessment (Health Care) - diagnosis
- Postoperative Complications - diagnosis
- Temporal Lobe - pathology