Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Unger, F; Walch, C; Schröttner, O; Eustacchio, S; Sutter, B; Pendl, G.
Cranial nerve preservation after radiosurgery of vestibular schwannomas.
Acta Neurochir Suppl. 2002; 84(6):77-83
Doi: 10.1007/978-3-7091-6117-3_9
PubMed
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- Führende Autor*innen der Med Uni Graz
- Unger Frank
- Co-Autor*innen der Med Uni Graz
- Eustacchio Sandro
- Schroettner Oskar
- Sutter Bernhard
- Walch Christian
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- Abstract:
- Radiosurgery is a management approach used to treat patients with vestibular schwannomas. The goals are long-term tumour growth control, maintenance of cranial nerve function and prevention of new deficiencies. We sought to determine long-term outcomes measuring the potential benefits against the neurological risks of primary radiosurgery. Gamma Knife radiosurgery was applied as a treatment modality for 289 patients with vestibular schwannomas from April 1992 to April 2002. The long-term results of 100 patients who underwent radiosurgery were evaluated. 60 patients received a primary treatment, 40 other cases presented with previously performed subtotal microsurgical resection or recurrence of disease (12-96 months, median 39). The median treatment volume was 3.4 ccm and the median dose to the tumour margin was 13 Gy. The median patient follow-up time was 76 months (range 60-120 months). Four tumours progressed after primary radiosurgery. Tumour control rate was 96%. Useful hearing (Gardner-Robertson I/II) was preserved in 16 patients (55%). Clinical neurological improvement occurred in 50%. Adverse effects comprised neurological symptoms (incomplete facial palsy) (House-Brackman II/III) in six cases (four recovered completely), mild transient trigeminal neuropathy in five cases, and morphological changes displaying rapid enlargement of preexisting macrocysts in two patients and tumour growth in two other patients. Microsurgical resection was performed in four cases (4%) and two patients underwent a shunting procedure because of hydrocephalus formation (2%). In patients who had undergone previous microsurgery, no new cranial nerve deficit was observed. Radiosurgery is an effective method for growth control of vestibular schwannomas and is associated with both a low mortality rate and a good quality of life. Accordingly, for the preservation of cranial nerve function radiosurgery is a useful method for the management of properly selected patients and is comparable to microsurgery.
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- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Cranial Nerves - pathology Cranial Nerves - physiopathology
- Facial Paralysis - diagnosis Facial Paralysis - physiopathology
- Female -
- Follow-Up Studies -
- Humans -
- Magnetic Resonance Imaging -
- Male -
- Microsurgery -
- Middle Aged -
- Neoplasm Recurrence, Local - diagnosis Neoplasm Recurrence, Local - physiopathology Neoplasm Recurrence, Local - surgery
- Neuroma, Acoustic - diagnosis Neuroma, Acoustic - physiopathology Neuroma, Acoustic - surgery
- Postoperative Complications - diagnosis Postoperative Complications - physiopathology
- Radiosurgery -
- Reoperation -
- Trigeminal Neuralgia - diagnosis Trigeminal Neuralgia - physiopathology