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Feigl, B; Haas, A; El-Shabrawi, Y.
Multifocal ERG in multiple evanescent white dot syndrome.
Graefes Arch Clin Exp Ophthalmol. 2002; 240(8):615-621 Doi: 10.1007/s00417-002-0478-7
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Leading authors Med Uni Graz: Feigl Beatrix
Co-authors Med Uni Graz: El-Shabrawi Yosuf; Haas Anton
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Abstract:: PURPOSE: To investigate the electrophysiological findings of a multifocal ERG in multiple evanescent white dot syndrome (MEWDS). METHODS: Multifocal electroretinograms (mf-ERG) were recorded from four patients with MEWDS. The stimulus array consisted of 61 hexagons and was presented according to a binary m-sequence. We analyzed the N1- and P1-wave amplitudes as well as P1 latencies of the first-order kernels. Local responses and concentric ring averaged responses were compared to 20 age-matched normal subjects. All patients underwent fluorescein angiography and indocyanine green angiography. RESULTS: In two patients, first-order kernel of N1- and P1-wave amplitudes showed supernormal results at the very beginning (day 1 to day 7) of the disease. By 2 weeks later, N1- and P1-wave amplitudes had decreased to either normal or subnormal values. The two patients who presented 2 weeks after the onset of clinical signs showed subnormal or decreased amplitudes. The P1 implicit times were within normal limits in all patients. CONCLUSION: Our mf-ERG findings show different results during the course of the disease. First-order kernel amplitudes seem to reflect early disturbances of the photoreceptors in MEWDS and are therefore useful in detecting early stages and following up the disease.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Coloring Agents - diagnostic use; Electroretinography - diagnostic use; Female - diagnostic use; Fluorescein Angiography - diagnostic use; Humans - diagnostic use; Indocyanine Green - diagnostic use; Retina - physiology; Retinal Diseases - diagnosis; Syndrome - diagnosis