Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Holzer, P.
Gastric mucosal protection signaled by peptidergic afferent neurons
DRUG NEWS PERSPECT. 1999; 12(8): 463-472.
Doi: 10.1358/dnp.1999.12.8.863639
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- Führende Autor*innen der Med Uni Graz
- Holzer Peter
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- Abstract:
- The maintenance of gastric mucosal integrity requires rapid alarm of protective mechanisms in the face of pending injury. Chemosensitive afferent neurons, which originate from dorsal root ganglia, monitor insults to the gastric mucosa and activate local mechanisms of defense through transmitter release from their peripheral endings. The transmitters involved comprise calcitonin gene-related peptide acting via CGRP(1) receptors, tachykinins acting via NK2 receptors and nitric oxide. By interacting with enteric and other autonomic neurons and with nonneural systems of defense, chemoceptive afferents enhance gastric blood flow, activate hyperemia-dependent and hyperemia-independent mechanisms of protection, and create favorable conditions for mucosal repair. Chemosensitive afferent neurons thus represent a neural alarm system in the mucosa of the stomach and other regions of the gut. The sensory neuron-selective expression of phenotypic traits such as vanilloid receptors provides novel pharmacological opportunities for the management of peptic ulcer disease. (C) 1999 Prous Science. All rights reserved.