Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Leithner, K; Leithner, A; Clar, H; Weinhaeusel, A; Radl, R; Krippl, P; Rehak, P; Windhager, R; Haas, OA; Olschewski, H.
Mesothelioma mortality in Europe: impact of asbestos consumption and simian virus 40.
Orphanet J Rare Dis. 2006; 1(3): 44-44.
Doi: 10.1186/1750-1172-1-44
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- Führende Autor*innen der Med Uni Graz
- Leithner Katharina
- Co-Autor*innen der Med Uni Graz
- Clar Heimo
- Krippl Peter
- Leithner Andreas
- Olschewski Horst
- Radl Roman
- Rehak Peter
- Windhager Reinhard
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- Abstract:
- Background: It is well established that asbestos is the most important cause of mesothelioma. The role of simian virus 40 (SV40) in mesothelioma development, on the other hand, remains controversial. This potential human oncogene has been introduced into various populations through contaminated polio vaccines. The aim of this study was to investigate whether the possible presence of SV40 in various European countries, as indicated either by molecular genetic evidence or previous exposure to SV40-contaminated vaccines, had any effect on pleural cancer rates in the respective countries. Methods: We conducted a Medline search that covered the period from January 1969 to August 2005 for reports on the detection of SV40 DNA in human tissue samples. In addition, we collected all available information about the types of polio vaccines that had been used in these European countries and their SV40 contamination status. Results: Our ecological analysis confirms that pleural cancer mortality in males, but not in females, correlates with the extent of asbestos exposure 25 - 30 years earlier. In contrast, neither the presence of SV40 DNA in tumor samples nor a previous vaccination exposure had any detectable influence on the cancer mortality rate in neither in males (asbestos-corrected rates) nor in females. Conclusion: Using the currently existing data on SV40 prevalence, no association between SV40 prevalence and asbestos-corrected male pleural cancer can be demonstrated.
- Find related publications in this database (using NLM MeSH Indexing)
- Asbestosis - mortality
- Causality -
- Comorbidity -
- Drug Contamination - statistics and numerical data
- Environmental Exposure - statistics and numerical data
- Environmental Exposure - epidemiology
- Female -
- Humans -
- Male -
- Mesothelioma - mortality
- Pleural Neoplasms - mortality
- Poliovirus Vaccines -
- Polyomavirus Infections - mortality
- Sex Distribution -
- Simian virus 40 -
- Survival Analysis -
- Survival Rate -
- Tumor Virus Infections - mortality