Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Grasser, B; Iberer, F; Schreier, G; Schaffellner, S; Kastner, P; Prenner, G; Hipmair, G; Wasler, A; Petutschnigg, B; Muller, H; Hutten, H; Schaldach, M; Tscheliessnigg, K.
Pacemaker system configuration for non-invasive rejection monitoring after heart transplantation
HEARTWEB. 1998; 4(1): U33-U37.
Web of Science
- Co-Autor*innen der Med Uni Graz
- Iberer Florian
- Müller Helmut
- Prenner Günther
- Tscheliessnigg Karlheinz
- Wasler Andrae
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- Abstract:
- We use implanted telemetric pacemakers and fractally coated epimyocardial leads to obtain serial recordings of paced ventricular electrograms for non-invasive rejection monitoring after heart transplantation. The rejection sensitive and the infection specific parameter are calculated from the ventricular evoked response. The repolarisation phase of the paced electrogram contains information on the functional and immunological status of the graft. The current pacemaker and lead configuration is designed for appropriate detection of the repolarisation phase of the intramyocardial electrogram. To eliminate interindividual differences, each patient is used as his own reference. Therefore, the reproducibility of the source signal is important for adequate graft monitoring. Electrodes with fractally coated tip reduces the polarization artifact and allow pacing and undisturbed detection of the paced electrogram using the same electrode. Unipolar signal detection allows to monitor the electrical activity of the whole heart and results in an improved presentation of the repolarisation phase of the electrogram. Pacemaker telemetry bandwidth influences the detection of the intramyocardial electrogram. The detection of low frequencies of the intramyocardial electrogram also improves the presentation of the repolarisation phase of the paced intramyocardial electrogram. Our current pacemaker system configuration (unipolar, fractally-coated electrodes, telemetry bandwidth 0,3 - 200 Hz) allows daily graft monitoring after heart transplantation.
- Find related publications in this database (Keywords)
- heart transplantation
- non-invasive rejection monitoring
- pacemaker system configuration
- pacemaker telemetry