Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Winklhofer-Roob, BM; Schlegel-Haueter, SE; Khoschsorur, G; van't Hof, MA; Suter, S; Shmerling, DH.
Neutrophil elastase/alpha 1-proteinase inhibitor complex levels decrease in plasma of cystic fibrosis patients during long-term oral beta-carotene supplementation.
Pediatr Res. 1996; 40(1):130-134
Doi: 10.1203/00006450-199607000-00022
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- Co-Autor*innen der Med Uni Graz
- Khoschsorur Gholamali
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- Abstract:
- Lung inflammation in cystic fibrosis (CF) is associated with an increased release from activated neutrophils of oxidants and proteinases. Free radical generation is not efficiently neutralized, and the major anti-proteinase, alpha 1-proteinase inhibitor (alpha 1-PI) is thought to be oxidatively inactivated. We hypothesized that enhanced antioxidant protection could represent an additional long-term strategy to attentuate the host inflammatory response. The effect on plasma neutrophil elastase/alpha 1-PI (NE/alpha 1-PI) complex levels (as a marker of lung inflammation) and plasma malondialdehyde concentrations (as a marker of lipid peroxidation) of additional oral beta-carotene supplementation was studied in 33 CF patients who had already received long-term vitamin E supplementation. In the presence of a more than 10-fold increase in plasma beta-carotene concentrations (mean +/- SEM) (0.09 +/- 0.01 to 1.07 +/- 0.19 mumol/L; p < 0.0001), a small increase in plasma alpha-tocopherol concentrations (23.8 +/- 1.31 to 28.4 +/- 1.81 mumol/L; p = 0.02), and a more than 50% decrease in plasma malondialdehyde concentrations (1.00 +/- 0.07 to 0.46 +/- 0.03 mumol/L; p < 0.0001), plasma NE/alpha 1-PI complex levels decreased from 102.2 +/- 16.0 to 83.0 +/- 10.4 micrograms/L; (p = 0.02). Plasma retinol concentrations increased (1.05 +/- 0.06 to 1.23 +/- 0.07 mumol/L; p = 0.0001) due to conversion of beta-carotene to retinol, which could have contributed to the decrease in NE/alpha 1-PI complex levels. Based on these results, we speculate that efficient antioxidant supplementation could attenuate lung inflammation in CF.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Oral -
- Adolescent -
- Adult -
- Antioxidants - therapeutic use
- Child - therapeutic use
- Child, Preschool - therapeutic use
- Cystic Fibrosis - blood
- Drug Administration Schedule - blood
- Female - blood
- Humans - blood
- Leukocyte Elastase - antagonists and inhibitors
- Lipid Peroxidation - drug effects
- Lipid Peroxides - blood
- Male - blood
- Neutrophils - enzymology
- Pancreatic Elastase - antagonists and inhibitors
- Serine Proteinase Inhibitors - blood
- Vitamin E - blood
- alpha 1-Antitrypsin - metabolism
- beta Carotene - therapeutic use