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Selected Publication:
Herbert, MK; Berg, W; Kublik, A; Holzer, P; Roewer, N.
Thio- and oxybarbiturates inhibit peristalsis in the Guinea-pig ileum in vitro
Anasthesiol Intensivmed Notfallmed Schmerzther. 2002; 37(12): 721-726.
Doi: 10.1055/s-2002-35912
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- Leading authors Med Uni Graz
- Herbert Michael K.
- Co-authors Med Uni Graz
- Holzer Peter
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- Abstract:
- INTRODUCTION: Inhibition of gastrointestinal motility by drugs used for anaesthesia or sedation in critically ill patients in the ICU is a major problem leading to various complications. Thus this study examines whether the thio- and oxybarbiturates thiopentone and pentobarbitone exert an inhibitory effect on intestinal peristalsis. METHODS: Peristalsis in isolated segments of the guinea-pig small intestine was elicited by distension of the gut wall through a rise of intraluminal pressure and recorded via the intraluminal pressure changes associated with the aborally moving peristaltic contractions. Thiopentone and pentobarbitone (0.1 - 300 microM)-induced inhibition of peristalsis was reflected by an increase of the peristaltic pressure threshold (PPT). RESULTS: Thiopentone (EC50 = 19,8 microM) and pentobarbitone (EC50 = 99.7 micro M) concentration-dependently increased the PPT. While the vehicle (saline) and 0.1 - 10 micro M thiopentone and pentobarbitone were without any effect on the PPT, 100 micro M caused a significant increase in PPT, and complete abolition of peristalsis occurred after 300 micro M thiopentone or pentobarbitone in all segments tested. Inhibition was reversed by changing the bath solution. CONCLUSIONS: Thio- and oxybarbiturates inhibit intestinal peristalsis in the guinea-pig ileum. It is assumed that thiopentone and pentobarbitone affect propulsive peristalsis also in the human small intestine.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Barbiturates - pharmacology
- Dose-Response Relationship, Drug - pharmacology
- Electromyography - pharmacology
- English Abstract - pharmacology
- Guinea Pigs - pharmacology
- Hypnotics and Sedatives - pharmacology
- Ileum - drug effects
- In Vitro - drug effects
- Muscle, Smooth - drug effects
- Pentobarbital - pharmacology
- Peristalsis - drug effects
- Pressure - drug effects
- Thiobarbiturates - pharmacology
- Thiopental - pharmacology
- Find related publications in this database (Keywords)
- barbiturates
- ileus
- gastrointestinal motility
- intensive care