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Yonei, Y; Holzer, P; Guth, PH.
Laparotomy-induced gastric protection against ethanol injury is mediated by capsaicin-sensitive sensory neurons.
Gastroenterology. 1990; 99(1):3-9 Doi: 10.1016/0016-5085(90)91222-R
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Co-authors Med Uni Graz: Holzer Peter
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Abstract:: Laparotomy significantly attenuates ethanol-induced gastric mucosal lesions in the rat. The effects of sensory denervation by capsaicin, indomethacin, atropine, guanethidine, and hexamethonium on laparotomy-induced protection were studied in the rat. Gastric mucosal injury was induced by the intragastric instillation of 1 mL of 75% ethanol. The laparotomy-induced protection against ethanol injury was abolished by sensory denervation by capsaicin (total dose, 125 mg/kg, SC) and also by pretreatment with indomethacin (5 mg/kg, SC). In contrast, pretreatment with atropine (0.5 mg/kg, IP), guanethidine (total dose, 20 mg/kg, SC), or hexamethonium (20 mg/kg, IP) had no significant effect on laparotomy-induced protection. These data indicate that capsaicin-sensitive sensory afferent neurons, but not cholinergic or adrenergic autonomic neurons, mediate laparotomy-induced protection against ethanol injury. The hypothesis is put forward that the protective response to laparotomy arises from a somatovisceral and/or viscerovisceral axon reflex of capsaicin-sensitive afferent neurons. Prostaglandins might play a mediator role in the activation by laparotomy of somatic and/or visceral branches of the afferent neurons.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Atropine - pharmacology; Capsaicin - pharmacology; Ethanol - toxicity; Ganglionic Blockers - pharmacology; Gastric Mucosa - drug effects; Guanethidine - pharmacology; Hexamethonium - pharmacology; Hexamethonium Compounds - pharmacology; Indomethacin - pharmacology; Laparotomy - pharmacology; Male - pharmacology; Neurons, Afferent - drug effects; Rats - drug effects; Rats, Inbred Strains - drug effects; Research Support, Non-U.S. Gov't - drug effects; Research Support, U.S. Gov't, Non-P.H.S. - drug effects; Research Support, U.S. Gov't, P.H.S. - drug effects