Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Heinemann, A; Jocic, M; Peskar, BM; Holzer, P.
CCK-evoked hyperemia in rat gastric mucosa involves neural mechanisms and nitric oxide.
Am J Physiol. 1996; 270(2 Pt 1): G253-G258.
Doi: 10.1152/ajpgi.1996.270.2.G253
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- Führende Autor*innen der Med Uni Graz
- Heinemann Akos
- Co-Autor*innen der Med Uni Graz
- Holzer Peter
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- Abstract:
- This study was performed to identify the possible neural mechanisms and mediators that underlie the gastric mucosal hyperemia evoked by cholecystokinin octapeptide (CCK-8). Gastric mucosal blood flow in anesthetized rats was assessed by the clearance of hydrogen and gastric acid secretion determined in the luminally perfused stomach. The gastric mucosal hyperemic effect of a low dose of CCK-8 (0.04 nmol/min iv infusion for 7 min) was abolished by inhibition of nitric oxide synthesis with NG-nitro-L-arginine methyl ester (15 mg/kg iv) and significantly blunted by defunctionalization of afferent neurons with a neurotoxic dose of capsaicin (125 mg/kg sc). The hyperemic reaction to a high dose of CCK-8 (0.2 nmol/min) was not significantly affected by these pharmacological maneuvers. The vasodilator response to low-dose CCK-8 (0.04 nmol/min) was further analyzed and found to be inhibited by acute bilateral subdiaphragmatic vagotomy, atropine (1 mumol/kg ip), and the antagonistic calcitonin gene-related peptide (CGRP) fragment CGRP-(8-37) (6 nmol/ min ia). Cyclooxygenase inhibition with indomethacin (10 mg/kg ip) was ineffective. The CCK-8-induced increment of gastric acid secretion was not significantly altered by any of these procedures. These results indicate that the gastric vasodilator effect of submaximal doses of CCK-8 is brought about by a vagovagal reflex that involves acetylcholine, CGRP or a related peptide, and nitric oxide as vasodilator messengers.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Calcitonin Gene-Related Peptide - pharmacology
- Capsaicin - pharmacology
- Female - pharmacology
- Gastric Acid - secretion
- Gastric Mucosa - blood supply
- Hyperemia - chemically induced
- NG-Nitroarginine Methyl Ester - pharmacology
- Nervous System Physiological Phenomena - pharmacology
- Nitric Oxide - antagonists and inhibitors
- Peptide Fragments - pharmacology
- Rats - pharmacology
- Rats, Sprague-Dawley - pharmacology
- Regional Blood Flow - drug effects
- Sincalide - pharmacology
- Vagotomy - pharmacology