Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Lippe, IT; Stabentheiner, A; Holzer, P.
Role of nitric oxide in the vasodilator but not exudative component of mustard oil-induced inflammation in rat skin.
Agents Actions. 1993; 38 Spec No(1): C22-C24.
Doi: 10.1007/BF01991125
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- Führende Autor*innen der Med Uni Graz
- Lippe Irmgard Theresia
- Co-Autor*innen der Med Uni Graz
- Holzer Peter
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- Abstract:
- The participation of nitric oxide (NO) in the neurogenic inflammatory reaction of the rat hindpaw skin to topical application of mustard oil was examined by the use of NG-nitro-L-arginine methyl ester (L-NAME, 43 mumol kg-1 i.v.), an inhibitor of NO formation. Control rats received the same dose of the inactive enantiomer D-NAME. Vasodilatation was recorded by contactless infrared emission thermography, and plasma protein exudation was measured by the Evans Blue leakage technique and by measurement of the paw volume in anaesthetized rats. L-NAME reduced the cutaneous hyperaemia caused by topical administration of mustard oil by about 50% but did not change the exudative reaction to mustard oil. These findings indicate that NO plays a mediator role in the vasodilator component of neurogenic inflammation in the rat paw skin, whereas the increase in vascular permeability does not appear to depend on NO.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Topical -
- Animals -
- Arginine - analogs and derivatives
- Dermatitis, Contact - metabolism
- Edema - chemically induced
- Exudates and Transudates - drug effects
- Female - drug effects
- Mustard Plant - drug effects
- NG-Nitroarginine Methyl Ester - drug effects
- Nitric Oxide - metabolism
- Plant Extracts - metabolism
- Plant Oils - metabolism
- Plants, Medicinal - metabolism
- Rats - metabolism
- Rats, Sprague-Dawley - metabolism
- Skin Temperature - drug effects
- Vasodilation - drug effects