Medizinische Universität Graz - Research portal
Selected Publication:
Holzer, P; Gamse, R; Lembeck, F.
Distribution of substance P in the rat gastrointestinal tract--lack of effect of capsaicin pretreatment.
Eur J Pharmacol. 1980; 61(3):303-307
Doi: 10.1016/0014-2999(80)90132-6
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- Leading authors Med Uni Graz
- Holzer Peter
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- Abstract:
- A new method for extraction of immunoreactive substance P (I-SP) from rat intestine including pulverization of tissue frozen in liquid nitrogen and extraction with acid acetone is described. Using this method, amounts of I-SP in the rat intestine were found to be higher than previously reported. The highest concentrations of I-SP were found in the small intestine. Capsaicin pretreatment of newborn or adult rats had no effect on intestinal I-SP concentrations indicating that intrinsic SP neurones are capsaicin-insensitive.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Animals, Newborn -
- Capsaicin - pharmacology
- Chromatography, Gel - pharmacology
- Digestive System - drug effects
- Drug Interactions - drug effects
- Fatty Acids, Unsaturated - pharmacology
- Female - pharmacology
- Ileum - metabolism
- Male - metabolism
- Rats - metabolism
- Substance P - analysis