Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Holzer, P; Jurna, I; Gamse, R; Lembeck, F.
Nociceptive threshold after neonatal capsaicin treatment.
Eur J Pharmacol. 1979; 58(4):511-514
Doi: 10.1016/0014-2999(79)90327-3
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- Führende Autor*innen der Med Uni Graz
- Holzer Peter
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- Abstract:
- The nociceptive threshold as determined by the reaction time in the hot-plate and tail-flick tests was measured 3 to 4 months after pretreatment of young rats with capsaicin (50 mg kg-1 s.c.). The reaction time in the tail-flick test was prolonged in rats pretreated with capsaicin on the 2nd day of life. Capsaicin pretreatment up to the 10th day of life also resulted in a prolonged reaction time in the hot-plate test whereas capsaicin pretreatment after the 10th day of life was without effect. The elevation of the nociceptive threshold after neonatal capsaicin pretreatment most likely follows from degeneration of afferent nerve fibres activated by noxious stimuli.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Animals, Newborn -
- Capsaicin - pharmacology
- Fatty Acids, Unsaturated - pharmacology
- Pain - physiopathology
- Rats - physiopathology
- Reaction Time - drug effects
- Sensory Thresholds - drug effects