Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Gamse, R; Holzer, P; Lembeck, F.
Indirect evidence for presynaptic location of opiate receptors on chemosensitive primary sensory neurones.
Naunyn Schmiedebergs Arch Pharmacol. 1979; 308(3):281-285
Doi: 10.1007/BF00501394
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- Co-Autor*innen der Med Uni Graz
- Holzer Peter
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- Abstract:
- 1. Rats were pretreated with 50 mg/kg s.c. capsaicin or solvent on the second day of life; 5 months later 3H-diprenorphine binding to homogenates of the whole spinal cord or of the upper dorsal horn of the spinal cord was investigated. 2. Capsaicin pretreatment resulted in a 17% decrease of opiate binding sites in the whole spinal cord and a 37% decrease in the upper dorsal horn with no change in their affinity. 3. Since neonatal capsaicin pretreatment causes degeneration of chemosensitive primary sensory neurones it is concluded that some opiate receptors are located presynaptically on the central terminals of these neurones.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Animals, Newborn - metabolism
- Capsaicin - pharmacology
- Diprenorphine - metabolism
- In Vitro - metabolism
- Narcotics - metabolism
- Neurons - metabolism
- Rats - metabolism
- Receptors, Opioid - drug effects
- Spinal Cord - metabolism
- Stereoisomerism - metabolism