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Selected Publication:
Holzer, P; Hagmüller, K.
Transient apnoea after systemic injection of GABA in the rat.
Naunyn Schmiedebergs Arch Pharmacol. 1979; 308(1):55-60
Doi: 10.1007/BF00499719
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- Leading authors Med Uni Graz
- Holzer Peter
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- Abstract:
- 1. I. v. or i.a. injection of GABA produced a transient apnoea in rats under pentobarbital anaesthesia. The dose-response relationship and specifity of this effect were investigated. 2. Injection of GABA into the femoral vein led to an apnoea of dose-dependent duration, the dose-response curve showed an ED50 of about 5 mumoles GABA kg-1 and a maximum duration of about 8 s. 3. The depressant action of systemic GABA on respiration seems to be specific as only close structural analogues of GABA such as trans-4-aminocrotonic acid, beta-hydroxy-GABA, delta aminovaleric acid, beta-alanine, and taurine were able to mimic the action of GABA. 4. Injection of these structural analogues of GABA 15 s rior to an injection of GABA inhibited the respiratory depressant effect of GABA dose-dependently. Picrotoxin also antagonized the apnoic action of GABA. 5. The results indicate that the apnoea induced by systemic injection of GABA is mediated by an action on GABA receptors.
- Find related publications in this database (using NLM MeSH Indexing)
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- gamma-Aminobutyric Acid - analogs and derivatives