Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Seifert, T; Zschörnig, O; Arnhold, J; Arnold, K.
Beta-blockers inhibit the modification of low-density lipoproteins by sodium hypochlorite in vitro.
Chem Phys Lipids. 1997; 85(1): 13-21.
Doi: 10.1016/S0009-3084(96)02637-0
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- Führende Autor*innen der Med Uni Graz
- Seifert-Held Thomas
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- Abstract:
- The effect of beta-blockers (alprenolol, oxprenolol, atenolol, acebutolol) and the non-steroidal anti-inflammatory drug, diclofenac, on modification of low-density lipoproteins (LDL) by sodium hypochlorite (NaOCl) was investigated in vitro. Beta-blockers and diclofenac inhibit the formation of thiobarbituric acid reactive substances in LDL modified by NaOCl. Beta-blockers, but not diclofenac, inhibit the hypochlorite-induced aggregation of LDL which was determined by photon correlation spectroscopy. The intracellular accumulation of cholesterol esters in J774 macrophages is inhibited by addition of beta-blockers, but not diclofenac, to LDL prior to the addition of NaOCl. The modification inhibiting effect of beta-blockers is inversely correlated to the binding capabilities of these substances to LDL which were assessed by laser electrophoresis. Inhibition of LDL modification in vivo by beta-blockers may reduce the risk of atherosclerosis and, therefore, compensate for the cholesterol-raising effect of these drugs in human plasma.
- Find related publications in this database (using NLM MeSH Indexing)
- Acebutolol - pharmacology
- Adrenergic beta-Antagonists - pharmacology
- Alprenolol - pharmacology
- Anti-Inflammatory Agents, Non-Steroidal - pharmacology
- Arteriosclerosis - metabolism
- Atenolol - pharmacology
- Bepridil - analogs and derivatives
- Chemistry - analogs and derivatives
- Cholesterol Esters - metabolism
- Diclofenac - pharmacology
- Free Radicals - metabolism
- Humans - metabolism
- Lipoproteins, LDL - metabolism
- Macrophages - drug effects
- Molecular Structure - drug effects
- Oxprenolol - pharmacology
- Particle Size - pharmacology
- Picrates - pharmacology
- Research Support, Non-U.S. Gov't - pharmacology
- Sodium Hypochlorite - pharmacology
- Spectrum Analysis - pharmacology
- Thiobarbituric Acid Reactive Substances - metabolism
- Find related publications in this database (Keywords)
- beta-blockers
- laser electrophoresis
- low-density lipoproteins (LDL)
- sodium hypochlorite
- zeta-potential
- J774 macrophages