Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Huppertz, B; Kadyrov, M; Kingdom, JC.
Apoptosis and its role in the trophoblast.
Am J Obstet Gynecol. 2006; 195(1): 29-39.
Doi: 10.1016/j.ajog.2005.07.039
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Huppertz Berthold
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- During early placentation the trophoblast of the human placenta differentiates to the villous and extravillous types of trophoblast. Villous trophoblast provides the epithelial cover of the placental villous trees in direct contact to maternal blood. Extravillous trophoblast invades maternal uterine tissues thus directly contacting maternal stromal and immune cells. A subset of extravillous trophoblast, endovascular trophoblast initially occludes the lumen of spiral arteries and comes into direct contact with maternal blood. In recent years apoptosis has been described in both types of trophoblast and the importance of this cascade for the normal function of the trophoblast has become obvious. One feature of serious conditions such as preeclampsia or intrauterine growth restriction is changes in apoptosis regulation in villous and/or extravillous trophoblast resulting in altered trophoblast invasion and/or shedding into the maternal circulation. This review summarizes recent findings on trophoblast apoptosis in normal and pathologic pregnancies.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Apoptosis - physiology
- Caspases - physiology
- Cell Line - physiology
- Cells, Cultured - physiology
- Female - physiology
- Fetal Growth Retardation - physiopathology
- Humans - physiopathology
- Pre-Eclampsia - physiopathology
- Pregnancy - physiology
- Proto-Oncogene Proteins c-bcl-2 - physiology
- Trophoblasts - physiology
- Find related publications in this database (Keywords)
- villous and extravillous trophoblast
- apoptosis
- invasion
- intrauterine growth
- preeclampsia