Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Reister, F; Kingdom, JC; Ruck, P; Marzusch, K; Heyl, W; Pauer, U; Kaufmann, P; Rath, W; Huppertz, B.
Altered protease expression by periarterial trophoblast cells in severe early-onset preeclampsia with IUGR.
J Perinat Med. 2006; 34(4):272-279
Doi: 10.1515/JPM.2006.052
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- Co-Autor*innen der Med Uni Graz
- Huppertz Berthold
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- Abstract:
- Adaptation of uteroplacental arteries in patients with early-onset preeclampsia combined with IUGR is compromised due to insufficient invasion of extravillous trophoblast cells (EVT) into the spiral artery wall. The underlying molecular mechanisms are widely unknown. We investigated expression and possible mechanisms of regulation of different matrix-metalloproteases (MMPs) by EVT in placental bed biopsies from patients with early onset preeclampsia combined with IUGR and healthy pregnant women. Expression of MMP-3 and MMP-7 by EVT was markedly reduced in preeclamptic patients, especially close to spiral arteries. In contrast to healthy pregnancies these cells strongly expressed the receptor for leukemia inhibitory factor (LIF). LIF is known to suppress MMP-expression and is produced by uterine natural killer (uNK) cells which we found to be present in higher concentrations in the placental bed of preeclamptic patients, and accumulating aside the spiral arteries. We speculate that in preeclampsia a maternal immune cell network accumulating and interfering in the placental bed leads to an altered cytokine environment, resulting in disturbed trophoblast cell function such as impaired MMP expression and reduced invasiveness.
- Find related publications in this database (using NLM MeSH Indexing)
- Apoptosis -
- Arteries - enzymology
- Case-Control Studies - enzymology
- Female - enzymology
- Fetal Growth Retardation - enzymology
- Humans - enzymology
- Infant, Newborn - enzymology
- Killer Cells, Natural - pathology
- Leukemia Inhibitory Factor - metabolism
- Matrix Metalloproteinase 3 - metabolism
- Matrix Metalloproteinase 7 - metabolism
- Models, Biological - metabolism
- Peptide Hydrolases - metabolism
- Placenta - blood supply
- Pre-Eclampsia - enzymology
- Pregnancy - enzymology
- Receptors, OSM-LIF - metabolism
- Trophoblasts - enzymology
- Find related publications in this database (Keywords)
- endovascular trophoblast invasion
- intrauterine growth restriction
- leukemia inhibitory factor
- macrophages
- matrix-metalloproteases
- periarterial trophoblast cells
- placental bed
- preeclampsia
- uterine natural killer cells
- uteroplacental arteries