Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Koestenberger, M; Gallistl, S; Bettina, L; Cimenti, C; Kutschera, J; Cvirn, G.
Effects of melagatran on activated partial thromboplastin time and on ecarin clotting time in cord versus adult plasma.
Blood Coagul Fibrinolysis. 2006; 17(8): 677-680.
Doi: 10.1097/01.mbc.0000252604.63142.e0
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Koestenberger Martin
- Co-authors Med Uni Graz
- Cimenti Christina
- Cvirn Gerhard
- Gallistl Siegfried
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Melagatran is the active form of the oral direct thrombin inhibitor ximelagatran. Melagatran does not require antithrombin as a cofactor. Its administration is therefore of special interest in neonatal patients, whose plasma is relatively deficient in antithrombin. We investigated the effects of increasing amounts of melagatran (0.05-1 micromol/l) on the activated partial thromboplastin time (APTT) and ecarin clotting time (ECT) in cord versus adult plasma. Both the APTT and ECT were dose-dependently prolonged in the presence of increasing amounts of melagatran. Furthermore, the ECT revealed a higher susceptibility of cord plasma to addition of melagatran than adult plasma. Whereas similar amounts of melagatran were required in cord and adult plasma samples to double the APTT (IC(50), 0.47 vs 0.46 micromol/l), significantly less melagatran was required in cord versus adult plasma to double the ECT (IC(50), 0.26 vs 0.56 micromol/l). Based on APTT measurements, similar plasma levels of melagatran might be required in neonates and in adults to treat thromboembolic complications. The APTT, however, is relatively insensitive to plasma melagatran concentrations. When the sensitive indicator ECT is used, results suggest that lower amounts of melagatran might be required in neonates than in adults. This has to be scrutinized in future clinical studies.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Anticoagulants - pharmacology
- Azetidines - pharmacology
- Benzylamines - pharmacology
- Endopeptidases - pharmacology
- Fetal Blood - drug effects
- Humans - drug effects
- Infant, Newborn - drug effects
- Partial Thromboplastin Time - drug effects
- Plasma - drug effects
- Find related publications in this database (Keywords)
- activated partial thromboplastin time
- cord plasma
- ecarin clotting time
- melagatran