Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Ginter, G; Petutschnig, B; Pierer, G; Soyer, HP; Reischle, S; Kern, T; de Hoog, S.
Case report. Atypical cutaneous pseudallescheriosis refractory to antifungal agents.
Mycoses. 1999; 42(7-8):507-511
Doi: 10.1046%2Fj.1439-0507.1999.00480.x
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Ginter-Hanselmayer Gabriele
- Co-Autor*innen der Med Uni Graz
- Soyer Hans Peter
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- Abstract:
- We report on a 65-year-old male heart transplant recipient who was otherwise in good condition. The patient was immunocompromised secondarily due to cyclosporin, prednisolone and azathioprine when widespread pustular skin lesions with erythematous margins subsequently developed on his left forearm. There was no history of trauma or septic temperature. Bacterial cultures were sterile and the results of native and cultural investigation studies were negative. A biopsy specimen of the lesion demonstrated hyalohyphomycosis with numerous septate hyphae within granulomas throughout the dermis. Subcutaneous tissues were not involved. Culture plates inoculated with pus and skin from the punch biopsy showed growth of a mould yielding Pseudallescheria boydii. Sensitivity testing was performed with miconazole, ketoconazole and itraconazole showing the best in vitro activity against P. boydii. In spite of treatment with itraconazole, the erythema and pustules continued to spread and therapy was changed to intravenous miconazole. Due to ongoing progression after 3 months of antifungal therapy surgical debridement was required. After 2 years of follow up, he had no recurrence.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Antifungal Agents - therapeutic use
- Dermatomycoses - drug therapy
- Humans - drug therapy
- Maduromycosis - drug therapy
- Male - drug therapy
- Pseudallescheria - isolation and purification
- Find related publications in this database (Keywords)
- Pseudallescheria Boydii
- Cutaneous Infection
- Heart Transplant
- Antimycotic Chemotherapy
- Itraconazole
- Miconazole
- Surgical Debridement