Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Halwachs, G; Iberer, F; Pieber, T; Müller, H; Tscheliessnigg, K; Tiran, A; Sabin, K; Wilders-Truschnig, M.
Troponin T as a marker for posttransplantation adaptational problems of the donor heart.
J Heart Lung Transplant. 1996; 15(5):451-455
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- Führende Autor*innen der Med Uni Graz
- Baumann Gabriele
- Co-Autor*innen der Med Uni Graz
- Iberer Florian
- Müller Helmut
- Pieber Thomas
- Tiran Andreas
- Truschnig-Wilders Martini
- Tscheliessnigg Karlheinz
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- Abstract:
- BACKGROUND: Troponin T is used as a marker for myocardial cell damage (e.g., in aiding diagnosis and follow-up of myocardial infarction). Elevated troponin T levels are also observed after heart transplantation, although until now no explanation could be found for this phenomenon. METHODS AND RESULTS: Serum samples of 15 patients who underwent orthotopic heart transplantation were tested for troponin T with a one-step enzyme immunoassay. The highest concentrations of troponin T were seen between day 3 and 14 after transplantation (3.05 +/- 1.30 micrograms/L) and remained elevated up to 3 months. A correlation (r = 0.61, p < 0.02) was found between pretransplantation systolic pulmonary artery pressure and the cumulative troponin T release after transplantation. No association was found with rejection, and no correlation was found with ischemic time of the donor heart. CONDITIONS: These findings support the hypothesis that the acute exposure of the donor heart to the preexisting elevated right ventricular afterload in the recipient represents a strong mechanical stress for the transplanted heart. Measurement of troponin T may therefore be helpful in the posttransplantation monitoring and management of ventricular function after orthotopic heart transplantation.
- Find related publications in this database (using NLM MeSH Indexing)
- Adaptation, Physiological -
- Adolescent -
- Adult -
- Biological Markers - blood
- Blood Pressure - blood
- Female - blood
- Follow-Up Studies - blood
- Graft Rejection - blood
- Heart Transplantation - physiology
- Humans - physiology
- Ischemia - physiology
- Male - physiology
- Middle Aged - physiology
- Myocardial Contraction - physiology
- Pulmonary Artery - physiology
- Systole - physiology
- Troponin - blood
- Troponin T - blood
- Ventricular Function, Right - blood