Medizinische Universität Graz - Research portal
Selected Publication:
von Ritter, C; Grisham, MB; Hollwarth, M; Inauen, W; Granger, DN.
Neutrophil-derived oxidants mediate formyl-methionyl-leucyl-phenylalanine-induced increases in mucosal permeability in rats.
Gastroenterology. 1989; 97(3):778-780
Doi: 10.1016/0016-5085(89)90654-9
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- Co-authors Med Uni Graz
- Höllwarth Michael
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- Abstract:
- The effects of several free radical scavengers and antioxidant enzymes on neutrophil-mediated changes in mucosal permeability (measured using blood-to-lumen clearance of 51Cr-labeled ethylene-diaminetetraactate) were assessed using ileal loops perfused with N-formyl-methionyl-leucyl-phenylalanine (FMLP). Neither superoxide dismutase nor catalase reduced the FMLP-induced increase in mucosal permeability. However, manganese-loaded desferrioxamine (a superoxide dismutase mimetic), PZ51 (a glutathione peroxidase analogue), desferrioxamine (an iron chelator), or dimethylsulfoxide (a hydroxyl radical scavenger) significantly attenuated FMLP-induced mucosal damage. The results of our experiments indicate that neutrophilic oxidants are responsible for a major portion of the mucosal permeability changes induced by FMLP.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antioxidants - pharmacology
- Chromium Radioisotopes - diagnostic use
- Edetic Acid - diagnostic use
- Free Radicals - diagnostic use
- Ileum - metabolism
- Intestinal Absorption - metabolism
- Intestinal Mucosa - metabolism
- N-Formylmethionine Leucyl-Phenylalanine - toxicity
- Neutrophils - metabolism
- Rats - metabolism
- Rats, Inbred Strains - metabolism
- Research Support, U.S. Gov't, P.H.S. - metabolism