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Binder, S; Bonnet, M; Velikay, M; Gerard, JP; Stolba, U; Wedrich, A; Hohenberg, H.
Radiation therapy in proliferative vitreoretinopathy. A prospective randomized study.
Graefes Arch Clin Exp Ophthalmol. 1994; 232(4):211-214 Doi: 10.1007/BF00184007
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Co-authors Med Uni Graz: Velikay-Parel Michaela; Wedrich Andreas
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Abstract:: In a prospective study of the effect of postoperative radiation therapy for the prevention of reproliferation of membranes and recurrent proliferative vitreoretinopathy (PVR) two similar groups of patients with retinal detachment and PVR grade D1 to D3 in one eye were compared. Half the eyes (30) received a total dose of 3000 cGy after surgery; the other half remained untreated. After a follow-up of 6 months and 14 months or more (maximum 36 months) the anatomical and functional results of each group were compared. After 6 months in the unirradiated group 57% (17/30) remained attached and 43% (13/30) had detached again. In the irradiated group 63% (19/30) were attached and 37% (11/30) had detached. However, there was no statistically significant difference between the two groups (P = 0.479, Fisher's Exact Test). After 14 months the number of cured and uncured eyes remained the same in the unirradiated group, while in four of the eyes in the irradiated group a later onset of reproliferation and detachment occurred (after 7, 8, 12 and 14 months, respectively). A final cure rate of 57% (17/30) was achieved in the unirradiated group and a 50% (15/30) cure rate in the irradiated group. Thus the failure rate was 43% (13/30) in the unirradiated group and 50% (15/30) in the irradiated group (P = 0.473, Fisher's Exact Test). No side effects from the radiation were observed in any case and no radiation retinopathy occurred during an observation period of up to 3 years.(ABSTRACT TRUNCATED AT 250 WORDS)
Find related publications in this database (using NLM MeSH Indexing): Adult -; Aged -; Cryotherapy -; Eye Diseases - radiotherapy; Female -; Follow-Up Studies -; Humans -; Male -; Middle Aged -; Prognosis -; Prospective Studies -; Radiotherapy Dosage -; Radiotherapy, High-Energy -; Recurrence -; Retinal Detachment - therapy; Retinal Diseases - radiotherapy; Scleral Buckling -; Visual Acuity -; Vitreous Body - radiation effects